EPOCH METABOLIC

The challenge

Your health check is measuring the wrong things.

Standard private medical screening detects disease that has already arrived. It cannot see the silent biological processes that precede it — sometimes by a decade or more.

Most senior professionals in demanding roles are experiencing measurable changes in their metabolic health, cardiovascular reserve, hormonal balance and rate of biological ageing — with no awareness of it, because none of these appear on a standard health check.

The consequences are quantifiable: declining cognitive sharpness, reduced energy, increased cardiovascular risk and the accumulation of biological debt that cannot be reversed by exercise alone.

The diseases we fear most in senior professionals — cardiac events, cognitive decline, burnout — share a common and measurable upstream biology. Standard screening cannot see it.

>15M

Pre-diabetes in the UKpeople living with pre-diabetes — the majority unaware. Most have a normal fasting glucose result on a standard health check. Insulin resistance is measurable a decade earlier. Diabetes UK, 2024

VO₂ max

The strongest predictor of longevityCardiorespiratory fitness is a more powerful predictor of all-cause mortality than hypertension, diabetes or smoking. It is not tested by any standard health screen. Mandsager et al., JAMA Network Open, 2018

>18 months

Cognitive impairment after burnoutDocumented cognitive dysfunction persisting beyond 18 months in clinical burnout — not resolved by rest alone. The biology driving it is measurable and modifiable. Deligkaris et al., Work & Stress, 2014

"You cannot out-exercise a broken metabolism. But you can diagnose the underlying cause, intervene and fix it." Dr Robin Fackrell — Medical Director, EPOCH METABOLIC

How it works

Four stages.
One complete picture.

Everything happens in a defined sequence. Every decision is grounded in your biology.

Deep biomarker assessment

Biomarkers measured include metabolic, cardiovascular, hormonal, sleep, epigenetic and functional domains — including blood pressure, BMI, body composition, lipid profile and insulin resistance. Blood draw at a clinic or at home — whichever suits you. Sleep analysis wearable delivered to you. Imaging appointment where clinically indicated.

One-to-one consultations

Results reviewed personally by both your Consultant Physician and your Specialist Dietitian before Day One. The programme is then built around what your biology reveals.

Residential programme

Five days at a premium private venue. Clinical consultations, personalised Metabolic Prescription, education and the foundation of lasting behaviour change.

12-week follow-up & retest

Six bi-weekly one-to-one online sessions supporting implementation and behaviour change. Full biomarker retest at 90 days confirms real biological change.

The result is not a report that sits in a drawer. It is a complete biological picture, a precision clinical plan and the support to make the change permanent — confirmed by objective data at 12 weeks.

The assessment

What we measure — and why it matters.

Most health checks measure six or seven markers. We measure 75+ across four core biological domains. The markers measured include those below — along with blood pressure, BMI, body composition (visceral fat and skeletal muscle mass) and a full lipid profile, all assessed in the context of your complete biological picture. Each tells part of the story. Together they create a picture that has never existed before for most of our clients.

You do not need a medical background to understand what we find. Our Consultant Physician presents every result in plain language — what it means for you and precisely what to do about it.

"By the time you arrive at the programme, your physician has already reviewed every result. Day One is a clinical consultation — not an intake."

The EPOCH Programme — included as standard

Metabolic & Insulin Signalling

Blood pressure · BMI · Visceral fat · Skeletal muscle mass · Fasting insulin · HOMA-IR · HbA1c · Full lipid profile · TG:HDL ratio · Omega-3 Index · ApoB · Lp(a) · Homocysteine · Uric acid · Waist-to-height ratio · Liver & kidney function

HPA Axis & Hormonal

Morning cortisol · DHEA-S:cortisol ratio · Testosterone · Oestradiol · Full thyroid panel · SHBG · Vitamin D (nmol/L)

Sleep Architecture

7-night wearable protocol · REM & deep sleep duration · Sleep efficiency · WASO · Nightly HRV

Functional Quality of Life

RAND-36 validated questionnaire · Vitality · Mental health · Role-emotional · Physical functioning · EPOCH Functional Index

Epigenetic Age

DunedinPACE biological clock · How fast you are currently ageing at a molecular level · Validated across 65+ cohorts in 17 countries · Responsive to the right intervention

Clinical extensions — added at clinical discretion after baseline review, not selected in advance

Cardiovascular Reserve Cardiac Chapter · available where clinically indicated

Cardiac MRI · CPET VO₂ max · BNP · Heart rate variability · Structural cardiac assessment at Alliance Medical

Neurological Risk Neurological Chapter · available where clinically indicated

Plasma NfL · GFAP · pTau217 via Quanterix Simoa · NeuroQuant volumetric brain MRI · ApoE genotype

The programme

Designed around your biology.
Not a template.

By addressing the six interconnected pillars of lifestyle medicine — nutrition, physical activity, restorative sleep, stress management, social connection and the avoidance of harmful substances — individuals can create a bespoke pathway to sustainable health, reversing chronic disease and optimising personal well-being.

Before you arrive

Complete biomarker workup

Blood draw at a clinic or at home. Sleep analysis wearable delivered to you for a seven-night baseline. Imaging appointment where clinically indicated. All results reviewed by your physician before Day One.

2–3 weeks before · No clinic visit required

The residential programme

Five days. Clinically led.

Day One: your physician and dietitian present every result together. Days Two to Five: personalised Metabolic Prescription delivery, sleep and circadian intervention, HPA axis restoration, cardiovascular protocol, education sessions and a written 90-day action plan. You leave knowing exactly what to do.

Lucknam Park, Bath · Group of typically 12

After the programme

12 weeks of support & retest

Six bi-weekly one-to-one online sessions with your Dietitian and health coach. Support for implementation, behaviour change and motivation — adapting the protocol as needed. A full biomarker retest at 90 days measures the biological change the programme has produced.

Included in all programmes · Objective outcomes confirmed at 90 days

The clinical team

Built by specialists.
Delivered by the founders.

Both founders are personally present for every client throughout the programme. This is not designed by one person and delivered by another.

Dr Robin Fackrell

BSc(Hons) MBBS FRCP MA

Medical Director & Co-Founder

I am a consultant physician with 25 years of clinical experience, fifteen specialising in neurodegeneration. I spent those years watching what metabolic and neurological dysfunction looks like when it arrives undetected. EPOCH is the earlier intervention that most of my patients needed years before they saw me.

GMC-registered Consultant Physician

Neurodegeneration specialist · 15 years at consultant level

Registered Manager

Amanda Overeynder

BSc(Hons) RD PGCE MRes

Operations Director & Co-Founder

The Metabolic Prescription is the clinical translation of what the biomarkers find. It is precision nutritional medicine — calibrated to your specific fasting insulin, cortisol rhythm, inflammatory profile and sleep architecture. I design and deliver it personally for every client and I lead the 12-week follow-up that makes it last.

HCPC-registered Dietitian

Metabolic health & clinical nutrition specialist

Deputy Manager

GMC & HCPCFull registration · Revalidation current

Professional IndemnityMedical Protection Society

GDPR RegisteredICO · Special category health data

What people say

From GPs and patients.
In their own words.

“Amanda’s talks at the beginning of the day — so well explained and put across. My introduction to metabolic wellness.”

Programme participant

“The professional, welcoming facilitator Amanda Overeynder made everything extremely clear. Her use of evidence-based research was so reassuring and clearly explained.”

Helen, Bath

“Really good in-depth knowledge and education around metabolic health. I found Amanda personable and very easy to follow — obviously passionate about her subject. Does the doing.”

Programme participant

“Amanda was really knowledgeable and helpful in answering questions. Practical sessions interspersed with theory worked really well.”

Programme participant

“Amanda was great — she presented information fantastically and made facts relatable. She’s inspiring.”

Louise F, Bath

“Amanda had the most impact on me — having such an insightful and caring approach to discussions and health outlook.”

Programme participant

“Amanda’s reassurance that I can take control of my health and choices for the better had a big impact on me.”

Fay, Bath

“In the current climate, where metabolic health is at the heart of so many chronic conditions, Dr Fackrell’s message felt not just relevant but essential.”

GP, Surrey

“Lifestyle change wasn’t presented as a ‘nice idea’ or something secondary to medication, but as the foundation for long-term positive health outcomes. That’s something we see all the time as GPs — when patients improve their nutrition, move more, sleep better and manage stress, their blood pressure improves, their glucose levels stabilise, their energy changes. Those shifts can genuinely alter the trajectory of disease.”

Dr N, GP

“His background as a consultant physician working in neurodegenerative disease gives him real authority on this topic. When you’re seeing the later stages of illness — dementia, complex neurological conditions — you also see the long-term consequences of poor metabolic and vascular health. Dr Fackrell balanced this really well: he wasn’t dismissing conventional medicine at all, but showing how lifestyle medicine complements it.”

Dr Lucy R, GP

“A consultation with Dr Fackrell was the most useful 45 minutes I’ve ever spent. His ability to actually listen, make you feel at ease and give his honest view was invaluable. He is so intelligent.”

Patient, Cheltenham

“Working alongside Amanda, a fantastic registered dietitian, added real depth — it reinforced that nutrition is not something we should oversimplify, and that multidisciplinary collaboration is key. Their interaction during the Q&A was particularly strong: balanced, evidence-based answers, practical advice and relaxed.”

GP, Surrey

“Amanda and Dr Fackrell are a great team.”

Simon, client at Metabolic Health

For organisations

Two distinct corporate programmes.
One clinical team.

Depending on where your senior people are, we offer two fundamentally different clinical programmes. Both are led personally by our founding physician and dietitian.

Health Optimisation Programme

For executives
who are at work.

Your highest-performing people are working at a biological cost that nobody has measured. Subclinical insulin resistance, accelerated biological ageing, cardiovascular deconditioning, HPA axis strain — none of these announce themselves. They accumulate quietly and the first visible sign is often a black swan event: a cardiac episode, a burnout-driven departure, a cognitive failure in a high-stakes moment.

We measure the biology before that moment arrives — and address it with precision. The result is executives who are measurably sharper, more resilient and operating closer to their biological peak than at any point in the preceding decade.

What this prevents

— Cardiac black swan events — structural changes visible on MRI years before any symptom

— Burnout-driven departures — the metabolic and neurological drivers are measurable and reversible when found early

— Silent cognitive decline — insulin resistance impairs executive function long before it impairs fasting glucose

What the organisation receives

An anonymised cohort-level biomarker report — a view of the biological health and resilience of your senior population that no other data source can provide. The first evidence base of its kind for your organisation.

Enquire about health optimisation

Executive Recovery Programme

For executives
who are off sick.

When a senior executive is absent through burnout, exhaustion, or a cardiac event, the standard pathway — GP referral, psychological support, phased return — addresses the psychological presentation. It does not address the metabolic and neurological biology that is sustaining the condition and determining the recovery trajectory.

We assess the biological substrate of the condition — insulin resistance, HPA axis exhaustion, neuroinflammation, cardiovascular deconditioning — and build a precision clinical intervention around what we find. The result is a faster, more complete return to work, grounded in objective biomarker evidence rather than symptom resolution alone.

What we address

— Burnout & exhaustion — metabolic, hormonal and neurological drivers that standard rehabilitation does not reach

— Post-cardiac recovery — cardiovascular reconditioning, metabolic correction and return-to-work capacity assessment

— Complex cognitive presentations — where the absence is driven by neurological as well as psychological factors

What the organisation receives

A structured clinical report within seven days of programme completion, including pre/post biomarker comparison, return-to-work capacity assessment and a 90-day support plan. Objective evidence of biological recovery — not just a functional assessment.

Enquire about executive recovery

The EPOCH Programme

£26,500

per person · group residential delivery · typically 12 participants

Includes

75+ biomarker assessment · Pre-programme physician review
Four-night residential at Lucknam Park, Bath
Individual EPOCH Index & clinical report
90-day precision action plan
12-week follow-up & full biomarker retest at 90 days

Clinical extensions — added at clinical discretion after baseline review, not selected in advance

Cardiac Chapter

Available where clinically indicated · pricing on discussion

Cardiac MRI and CPET VO₂ max at Alliance Medical. For clients where cardiovascular reserve or family history warrants structural cardiac assessment.

Neurological Chapter

Available where clinically indicated · pricing on discussion

NeuroQuant brain MRI, plasma NfL, GFAP and pTau217 via Quanterix Simoa and ApoE genotype. For clients with neurological family history or specific cognitive risk indicators.

Whole Body Chapter

Available where clinically indicated · pricing on discussion

Full-body MRI — no radiation, no contrast agent, ~90 minutes — reviewed by your physician in the context of your complete EPOCH findings. Available where clinically indicated.

Bespoke configuration

Something different in mind?

Different group size, specific clinical priorities, exclusive-use venue, GIP insurer pathway or a configuration not covered above — we build around the clinical requirement. Pricing by discussion.

Begin the conversation →

Founding cohort — October 2026. Founding participants work directly with both founders throughout. Standard programme pricing applies to all founding cohort clients.

Begin the conversation

Know your biology.
Change your future.

Your health check is measuring the wrong things.

Four stages.
One complete picture.

What we measure — and why it matters.

Designed around your biology.
Not a template.

Built by specialists.
Delivered by the founders.

From GPs and patients.
In their own words.

Two distinct corporate programmes.
One clinical team.

For executives
who are at work.

For executives
who are off sick.

The biology is there.
It just needs to be found.

Individual programme

Health optimisation

Executive recovery

Speak with Robin or Amanda

Know your biology.Change your future.

Your health check is measuring the wrong things.

Four stages.One complete picture.

What we measure — and why it matters.

Designed around your biology.Not a template.

Built by specialists.Delivered by the founders.

From GPs and patients.In their own words.

Two distinct corporate programmes.One clinical team.

For executiveswho are at work.

For executiveswho are off sick.

The biology is there.It just needs to be found.

Individual programme

Health optimisation

Executive recovery

Speak with Robin or Amanda

Know your biology.
Change your future.

Four stages.
One complete picture.

Designed around your biology.
Not a template.

Built by specialists.
Delivered by the founders.

From GPs and patients.
In their own words.

Two distinct corporate programmes.
One clinical team.

For executives
who are at work.

For executives
who are off sick.

The biology is there.
It just needs to be found.